ADIPRIDE M 2MG is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. It is used to treat type II diabetes mellitus when diet, exercise and treatment with other single agents did not result in adequate response. Type II diabetes mellitus is a chronic medical condition in which the body cannot properly utilize the circulating sugars (glucose) from the blood to make energy. As a result, the patient experience sudden unintentional weight loss, extreme tiredness, increased urination, thirst or hunger and slow healing ulcers. If left untreated, it can cause permanent damage to the nerves in the body and may to lead to other life-threatening complications.
Glimepiride is a sulfonylurea which acts by making the pancreas secrete more insulin to digest the circulating glucose and metformin is biguanide which acts by blocking the production of glucose by the liver. ADIPRIDE M 2MG decrease blood glucose levels and makes the body respond better to insulin.
While taking ADIPRIDE M 2MG, patients must continue to take carbohydrate-regularized diet as instructed by their doctor to obtain better results. Before taking ADIPRIDE M 2MG inform your doctor if you have type 1 diabetes mellitus, severe liver or kidney diseases, or heart problems. ADIPRIDE M 2MG is not recommended for use in pregnant and breastfeeding women. The common side effects of ADIPRIDE M 2MG are nausea, vomiting, diarrhea, stomach pain and changes in taste.
USES OF ADIPRIDE M 2MG
Treat type II diabetes mellitus when diet, exercise and other single agents does not provide adequate response
HOW ADIPRIDE M 2MG WORKS
ADIPRIDE M 2MG effectively reduces elevated blood glucose levels, where glimepiride acts by making the pancreas secrete more insulin to digest the circulating glucose and metformin acts by blocking the production of glucose by the liver. They collectively decrease the elevated blood glucose levels and makes the body respond better to insulin.
DIRECTIONS FOR USE
Take ADIPRIDE M 2MG as instructed by your doctor. Swallow it as whole and do not crush or chew it. Do not stop taking ADIPRIDE M 2MG unless your doctor tells you to stop.
SIDE EFFECTS OF ADIPRIDE M 2MG
Diarrhea, stomach pain, loss of appetite
Changes in taste
Low blood sugar levels
Changes in blood counts (increased tendency to bleed, increased infections, weakness, pale skin)
Stop taking ADIPRIDE M 2MG and consult your doctor immediately, if you experience
Signs of lactic acidosis (such as generalized weakness and tiredness, vomiting, stomach pain, muscle pain, difficulty in breathing, reduced body temperature and decreased heartbeat)
Signs of dehydration (such as severe vomiting, diarrhea, fever,
exposure to heat)
Signs of liver problems (such as liver inflammation leading to yellowing of eyes and skin)
Signs of allergic reaction (such as skin rash, itching, inflammation of blood vessels, difficulty in breathing, decrease in blood pressure, shock, increased sensitivity to sun)
Severe hypoglycaemia which may cause unconsciousness, seizures, or coma
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to take ADIPRIDE M 2MG with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. This side effect can be seen usually while taking ADIPRIDE M 2MG and would stop within two weeks of therapy. However, consult your doctor if they persist longer.
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. This side effect can be seen usually while taking ADIPRIDE M 2MG and would stop within two weeks of therapy. However, consult your doctor if they persist longer
Low blood sugar:
During signs of low blood sugar levels, immediately consume a meal or a snack which is rich in sugars like sweets, biscuits, or fruit juice. Follow the carbohydrate-regularized diet as instructed by your doctor to obtain better results. Consult your doctor if the signs of low blood sugar levels do not improve.
WARNING & PRECAUTIONS
ADIPRIDE M 2MG is generally not recommended for use in pregnant women. Consult your doctor before taking.
ADIPRIDE M 2MG is generally not recommended for use in breast feeding women. Consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or operate any tools or machines if you experience signs of low blood sugar levels (like dizziness or fainting) while taking ADIPRIDE M 2MG.
Avoid alcohol consumption while taking ADIPRIDE M 2MG as it could further increase blood glucose levels.
ADIPRIDE M 2MG is not recommended for use in patients who have severe kidney impairment. Consult your doctor before taking.
ADIPRIDE M 2MG is not recommended if you have severe liver disease. Consult your doctor before taking.
Do not take ADIPRIDE M 2MG if you are allergic to Metformin, Glimepiride or other sulphonylureas (such as glibenclamide, gliclazide) or sulfonamides (Ex. sulphamethoxazole).
ADIPRIDE M 2MG is not recommended for use in patients having severe infection in the lungs or in the respiratory tract. Consult your doctor before taking.
ADIPRIDE M 2MG is not recommended for use if you:
Have metabolic acidosis (buildup of acids or ketone bodies in the body which can cause sever weakness, dizziness, nausea, stomach pain, muscle pain which could be fatal)
Have diabetic coma (high blood glucose levels causing unconsciousness)
Have severe dehydration, severe infection, or shock
Have uncontrollable diabetes or type I diabetes (insulin-dependent diabetes)
Before taking ADIPRIDE M 2MG, inform your doctor if you:
Recently had an injury, operation, fever with infections or under any other stressful condition
Malnourished or not eating your meals properly (irregular mealtime or skipped meals)
Recently made changes in your diet
Have hormonal imbalance (Ex. thyroid disorders)
Are doing high intensity exercises without proper energy-rich nutrient diet
Are scheduled for a surgery
Use in Pediatrics:
ADIPRIDE M 2MG is generally not recommended for use in children and adolescents under 18 years of age. Kindly consult your doctor before taking.
Use in Geriatrics:
ADIPRIDE M 2MG should be used with caution in elderly patients. Kindly consult your doctor before taking.
A. Drug – Drug interactions:
Before taking ADIPRIDE M 2MG, inform your doctor if you are taking,
Medicines used to treat pain and inflammation (such as aspirin, ibuproefen, celecoxib, oxyphenbutazone, phenylbutazone, azopropazone)
Other medicines used to treat diabetes (such as insulin, glyburide)
Anabolics (used to increase muscle buildup) Ex. nandrolone, oxymetholone
Medicines used for blood thinning (Ex. warfarin)
Fenfluramine (used to treat obesity)
Medicines used to heart problems (Ex. captopril, enalapril, propranolol, disopyramide, methyldopa, clonidine, reserpine, diazoxide)
Diuretics (used to increase urine output) Ex. hydrochlorothiazide, furosemide
Medicines used to treat high blood cholesterol levels (Ex. clofibrate, fenofibrate, nicotinic acid, colesevalam)
Medicines used to treat depression (such as isocarboxazid, phenelzine, selegiline, tranylcypromine, fluoxetine, citalopram).
Medicines used to treat gout (Ex. allopurinol, probenecid, sulfinpyrazone)
Medicines used to treat certain forms of cancer (Ex. crizotinib, olaparib trofosfamide, cyclophosphamide, ifosfamide)
Fluconazole, isavuconazole, miconazole (used to treat fungal infections)
Tritoqualine (used to treat nasal congestion caused due to allergic reactions)
Pentoxifylline (used to treat circulatory disorders)
Medicines used to treat urinary tract infections (Ex. cotrimoxazole)
Testosterone (used to regulate male hormone in the body)
Estrogen and progesterone containing medicines (used to regulate female hormones in the body)
Levothyroxine (used to treat thyroid deficiency)
Corticosteroids (used to treat pain and inflammation) Ex. prednisolone, dexamethasone, betamethasone
Medicines used to treat mental illness (Ex. chlorpromazine, mesoridazine, fluphenazine)
Medicines that have stimulatory effects in the body (Ex. adrenaline, amphetamine)
Medicines to treat constipation (Ex. lactulose)
Phenytoin (used to treat epilepsy)
Glucagon (used to treat severe low blood sugar levels)
Barbiturates (used to induce sleep) Ex. phenobarbital
Rifampicin (used to treat tuberculosis)
Acetazolamide (used to treat glaucoma)
Ranitidine, cimetidine (used to treat stomach ulcers)
Injection of contrast medium (used for diagnostic purpose)
Dolutegravir (used to treat viral infections)
Ranolazine (used to treat chest pain)
Vandetanib (used to treat tumors of thyroid gland)
If you or anyone else accidentally take too much of ADIPRIDE M 2MG, consult your doctor immediately. Overdose may cause signs of lactic acidosis (such as generalized weakness and tiredness, vomiting, stomach pain, muscle pain, difficulty in breathing, reduced body temperature and decreased heartbeat).